Cyclin B1 mouse Monoclonal Antibody(5C1), 50ul Filtration COPS2 is an essential component

COPS2 is an essential component of the COP9 signalosome complex (CSN)

The protein encoded by POLR1C (RNA polymerase I subunit C) is a subunit of both RNA polymerase I and RNA polymerase III complexes

This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte

Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain

The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors

Cyclin B1 mouse Monoclonal Antibody(5C1), 50ul Filtration COPS2 is an essential componentThe protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle regulated transcript, that is expressed predominantly during G2 M phase. The different transcripts result from the use of alternate transcription initiation sites.