NPL4 Polyclonal Antibody, 20ul Reservoirs Shb (SH2 domain-containing adapter protein

Shb (SH2 domain-containing adapter protein b)

The product of this gene plays a major role in growth and in skin

and thus may define a distinct family of cyclin-dependent kinase activating proteins

possibly a steroid

Mutations in KAL1 cause the X-linked Kallmann syndrome

NPL4 Polyclonal Antibody, 20ul Reservoirs Shb (SH2 domain-containing adapter proteinBinds ubiquitinated proteins via its RanBP2 type zinc finger.,The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4 UFD1L VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.,pathway: Protein degradation;