NEIL1 Polyclonal Antibody, 50ul Gene Synthesis The erythroid-specific protein encoded by

The erythroid-specific protein encoded by this gene| and the ubiquitous transcription factor CP2| form the stage selector protein (SSP) complex| which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells

A mutation in this gene results in AICA-ribosiduria

particularly the cerebellum

The protein encoded by this gene is a member of the TNF-receptor superfamily| and contains an intracellular death domain

as well as the EDG family of proteins

NEIL1 Polyclonal Antibody, 50ul Gene Synthesis The erythroid-specific protein encoded byNEIL1 is a member of the Nei endonuclease VIII like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene.