SLAF7 Polyclonal Antibody, 50ul In vitro Transcription GAB2 (GRB2 associated binding protein

GAB2 (GRB2 associated binding protein 2) is a member of the GRB2-associated binding protein (GAB) gene family

Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family| but not in similar patients of European descent

Defects in this gene are frequently found in patients with prostate tumors

The protein encoded by ELAC2 (elaC ribonuclease Z 2) has a C-terminal domain with tRNA processing endoribonuclease activity

3 bisphosphoglycerate (2

SLAF7 Polyclonal Antibody, 50ul In vitro Transcription GAB2 (GRB2 associated binding proteinIsoform 1 mediates NK cell activation through a SAP independent extracellular signal regulated ERK mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro).,Contains 1 Ig like C2 type (immunoglobulin like) domain.,tissue specificity: Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow,