NRX1B Polyclonal Antibody, 20ul Subcellular Fractions Sporadic and familial mutations in

Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma

This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family

and found to form heteropentamer swithNP1 andNP2

These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs| RNP1 and RNP2| originally described in RNA binding proteins| and required for DNA binding

such as cell cycle regulation

NRX1B Polyclonal Antibody, 20ul Subcellular Fractions Sporadic and familial mutations inalternative products: A number of isoforms are produced by alternative promoter usage including the alpha type (shown here) and beta type (AC P58400) isoforms which differ in their N terminus. Additional isoforms may be produced by alternative splicing,alternative products: A number of isoforms, alpha type (AC Q9ULB1) and beta type (shown here), are produced by alternative promoter usage. Beta type isoforms differ from alpha type isoforms in their N