PDK1 Polyclonal Antibody, 20ul[BT-AP07028] Molecular Weight Markers Mutations in ATP7A are associated

Mutations in ATP7A are associated with Menkes disease

a glycine- and serine-rich region (called the GS domain) preceding the kinase domain

GO annotations related to this gene include calcium ion binding

as only a minority of individuals showed biased expression from the maternal allele

Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses

PDK1 Polyclonal Antibody, 20ul[BT-AP07028] Molecular Weight Markers Mutations in ATP7A are associatedPyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced