O-FucT-1 Polyclonal Antibody, 100ul Cytokines Alternative transcriptional splice variants have

Alternative transcriptional splice variants have been found for this gene

and expression of this gene may play a role in the progression of multiple types of cancer

and confers oncogenic transformation of primary cells

The encoded protein is part of a large protein complex called ASCOM

The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK)

O-FucT-1 Polyclonal Antibody, 100ul Cytokines Alternative transcriptional splice variants havePOFUT1 encodes a member of the glycosyltransferase O Fuc family. This enzyme adds O fucose through an O glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor like repeats of a number of cell surface and secreted proteins. O fucose glycans are involved in ligand induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms.