RN139 Rabbit Polyclonal Antibody, 20ul Diagnostic Probes & Oligos The BinCARD gene maps to

The BinCARD gene maps to chromosome 9q22

This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment

while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1

The various isoforms have functional differences| with respect to ARF GAP activity and to G

catalyzes the formation of phosphoenolpyruvate from oxaloacetate

RN139 Rabbit Polyclonal Antibody, 20ul Diagnostic Probes & Oligos The BinCARD gene maps toThe protein encoded by this gene is a multi membrane spanning protein containing a RING H2 finger. This protein is located in the endoplasmic reticulum and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3: 8) translocation in a family with hereditary renal and non medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL