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This gene encodes a protein sharing a low level of sequence similarity with human ribosomal protein L24

and directly interacts with the tumor suppressor p53 to reduce p53 transcriptional activity by reducing p53 protein level in the absence of DNA damage

Multiple alternatively spliced transcript variants have been described

Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA)

Na+ CP type Alpha-pan Polyclonal Antibody, 100ul Modification Enzymes Enhance your laboratory filtration processSCN9A (sodium voltage gated channel alpha subunit 9) encodes a voltage gated sodium channel which plays a significant role in nociception signaling. Mutations in SCN9A have been associated with primary erythermalgia, channelopathy associated insensitivity to pain, and paroxysmal extreme pain disorder.