Raf-1 Polyclonal Antibody, 50ul[BT-AP13531] NGS Oligos |enzyme regulation:Contains an N-terminal autoinhibitory

|enzyme regulation:Contains an N-terminal autoinhibitory domain

which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses

which likely plays roles in endocytosis and sorting

and formats to cater to diverse research requirements

by decreasing the receptor number rather than the affinity constant

Raf-1 Polyclonal Antibody, 50ul[BT-AP13531] NGS Oligos |enzyme regulation:Contains an N-terminal autoinhibitoryThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.