F90A9 Rabbit Polyclonal Antibody, 50ul DNA Fragments Defects in TMEM237 are a

Defects in TMEM237 are a cause of Joubert syndrome-14

This gene encodes a Rho-GTPase activating protein

The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK)

It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates

the highest levels can be found in skeletal muscle

F90A9 Rabbit Polyclonal Antibody, 50ul DNA Fragments Defects in TMEM237 are aFAM90A9 belongs to subfamily II of the primate specific FAM90A gene family which originated from multiple duplications and rearrangements (Bosch et al. 2007