Ref-1 Polyclonal Antibody, 50ul[BT-AP07734] Sample Library Tubes Single nucleotide polymorphisms in REL

Single nucleotide polymorphisms in REL are associated with susceptibility to ulcerative colitis and rheumatoid arthritis

Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2)

In addition to its role in regulating the later stages of terminal differentiation of keratinocytes

This gene encodes a protein containing four putative zinc finger motifs

The function of this protein is unknown

Ref-1 Polyclonal Antibody, 50ul[BT-AP07734] Sample Library Tubes Single nucleotide polymorphisms in RELApurinic apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. APEX1 encodes the major AP endonuclease in human cells.