Mouse Poly Adp Ribose Polymerase 2, PARP2 ELISA Kit, 96T Bottles Defects in EIF2B4 are a

Defects in EIF2B4 are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy

Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site

Mutations in this gene have been associated with autosomal recessive dilated cardiomyopathy

May have roles in neural function

PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine

Mouse Poly Adp Ribose Polymerase 2, PARP2 ELISA Kit, 96T Bottles Defects in EIF2B4 are aPoly ADP ribosyltransferase that mediates poly ADP ribosylation of proteins and plays a key role in DNA repair (PubMed: 10364231). Mediates glutamate, aspartate or serine ADP ribosylation of proteins: the ADP D ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP ribosyl groups are transferred to the 2' position of the terminal adenosine moiety, building up a polymer with an average chain length of