Human Rho Gtpase-activating Protein 22, ARHGAP22 ELISA Kit , 96T sgRNA Library Construction This gene encodes a member

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins

Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed: 11812992

The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor

Under conditions of nutrient depletion

A subtype of IgA pemphigus| a life-threatening autoimmune disease| is characterized by the presence of autoantibodies that target the encoded protein

Human Rho Gtpase-activating Protein 22, ARHGAP22 ELISA Kit , 96T sgRNA Library Construction This gene encodes a memberRho GTPase activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP bound state. Inhibits RAC1 dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin 1 (EDN1) promoter (By similarity).