Raf-1(Phospho Thr269) Polyclonal Antibody, 100ul Mammalian Expression Mutations in this gene have

Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders

An important paralog of this gene is ERAP2

This gene was identified by the interaction of its gene product with Grap2

CLIP2 is hemizygously deleted in Williams syndrome

Two transcript variants encoding different isoforms have been found for PLCG1

Raf-1(Phospho Thr269) Polyclonal Antibody, 100ul Mammalian Expression Mutations in this gene haveThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.