SOCS7 Polyclonal Antibody, 20ul In vitro Assessment AKR1C3 shares high sequence identity

AKR1C3 shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14

a member of Tec tyrosine kinase family characterized by a multimodular structures including PH

interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes

and weakly in heart

seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain

SOCS7 Polyclonal Antibody, 20ul In vitro Assessment AKR1C3 shares high sequence identityThe SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.,Regulates signaling cascades probably through protein ubiquitination and or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits