Tcl1 Polyclonal Antibody, 100ul Cell Biology The type I cytokeratins are

The type I cytokeratins are clustered in a region of chromosome 17q21

Contains 1 SSD (sterol-sensing) domain

Four transcript variants encoding two different isoforms have been found for this gene

The encoded protein consists of four N-terminal immunoglobulin-like domains| six fibronectin type III domains| a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC

is tightly regulated in normal cells but is frequently deregulated in human cancers

Tcl1 Polyclonal Antibody, 100ul Cell Biology The type I cytokeratins areOverexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T cell antigen receptor (TCR) alpha (MIM 186880) or TCR beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998