HXB7 Polyclonal Antibody, 50ul 3D Cell Culture Consumables The nuclear protein binds to

The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes

The encoded protein is also a putative tumor suppressor protein| and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia

This gene uses alternative transcription start sites

cell cycle arrest

apoptosis and cellular transformation

HXB7 Polyclonal Antibody, 50ul 3D Cell Culture Consumables The nuclear protein binds toThis gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.