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RPA p32(Phospho Ser33) Polyclonal Antibody, 50ul Gene Synthesis 1987 [PubMed 2446322]

SKU: 45423079142

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RPA p32(Phospho Ser33) Polyclonal Antibody, 50ul Gene Synthesis 1987 [PubMed 2446322]Required for DNA recombination, repair and replication. The activity of RP A is mediated by single stranded DNA binding and protein interactions.,PTM: Phosphorylated in a cell cycle dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC DNA PK in the presence of Ku and DNA, and by CDC2.,subcellular location: Also present in PML

Store: gaabil.dk · Domain: gaabil.dk

Description

1987 [PubMed 2446322]

The encoded protein is localized in the inner membrane and facilitates the rapid transport and exchange of molecules between the cytosol and the mitochondrial matrix space

It also stimulates the formation and secretion of plasminogen activator by synovial cells

which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes

Together with neurophysin

RPA p32(Phospho Ser33) Polyclonal Antibody, 50ul Gene Synthesis 1987 [PubMed 2446322]Required for DNA recombination, repair and replication. The activity of RP A is mediated by single stranded DNA binding and protein interactions.,PTM: Phosphorylated in a cell cycle dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC DNA PK in the presence of Ku and DNA, and by CDC2.,subcellular location: Also present in PML

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