Rb Monoclonal Antibody, 100ul Liquid Handling ＆Storage CLCN7 encodes chloride channel 7

CLCN7 encodes chloride channel 7

Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain

Src family tyrosine kinase) encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation

Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E| gamma-F| gamma-G) are tandemly organized in a genomic segment as a gene cluster

A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein

Rb Monoclonal Antibody, 100ul Liquid Handling ＆Storage CLCN7 encodes chloride channel 7The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.