MER/TYRO3(Phospho-Tyr753/Tyr685) Polyclonal Antibody, 100ul Diagnostic Probes & Oligos Pendred syndrome

Pendred syndrome

|Important for the overall degradation of proteins in lysosomes

The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5

In a conventional activation pathway| I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators| subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus

which results in viral RNA degradation and the inhibition of viral replication

MER/TYRO3(Phospho-Tyr753/Tyr685) Polyclonal Antibody, 100ul Diagnostic Probes & Oligos Pendred syndromeThis gene is a member of the MER AXL TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type III domains, two Ig like C2 type (immunoglobulin like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).