Neu Polyclonal Antibody, 100ul[BT-AP05903] Roller Bottles Alternative splicing of TP63 and

Alternative splicing of TP63 and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties

Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy

The protein encoded by this gene is found in both mitochondria and the nucleus| where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters

and xenobiotics (Lukacik et al

Not expressed in other normal tissues

Neu Polyclonal Antibody, 100ul[BT-AP05903] Roller Bottles Alternative splicing of TP63 andERBB2 encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. Erb b2 receptor tyrosine kinase 2 has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase mediated activation of downstream signalling pathways, such as those involving