M-CSF Receptor(Phospho-Tyr546) Rabbit Polyclonal Antibody, 20ul Pipette Controller It is predominantly expressed in

It is predominantly expressed in the pituitary gland

based on the arrangement of the first 2 of the 4 conserved cysteine residues

Additional splice variants have been described but sequences for the complete transcripts have not been determined

A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis

The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner

M-CSF Receptor(Phospho-Tyr546) Rabbit Polyclonal Antibody, 20ul Pipette Controller It is predominantly expressed inThe protein encoded by this gene is the receptor for colony stimulating factor 1 a cytokine which controls the production differentiation and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1 PDGF