SVOP Polyclonal Antibody, 50ul Dialysis ITCH (itchy E3 ubiquitin protein

ITCH (itchy E3 ubiquitin protein ligase) encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases

The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor

tissue specificity:Predominantly expressed in brain and adrenal gland

which suggests its role in PI(3) kinase-mediated signaling events

Experiments with knockout mice indicate that this gene attenuates

SVOP Polyclonal Antibody, 50ul Dialysis ITCH (itchy E3 ubiquitin proteinSVOP (SV2 Related Protein) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SV2C.