CdGAP(Phospho Thr789) Polyclonal Antibody, 20ul Cell Screening and Imaging SEMA4A encodes a member of

SEMA4A encodes a member of the semaphorin family of soluble and transmembrane proteins

Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein

These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases

which act as heat shock protein 70 cochaperones

Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL)

CdGAP(Phospho Thr789) Polyclonal Antibody, 20ul Cell Screening and Imaging SEMA4A encodes a member ofThis gene encodes a GTPase activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth.