MDMX Polyclonal Antibody, 100ul CellSafe™ The gamma globin genes (HBG1

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver| spleen and bone marrow

processing and nuclear export

It is located mainly in dense fibrillar regions of the nucleolus

This gene is a candidate meningioma gene

including interleukin 6

MDMX Polyclonal Antibody, 100ul CellSafe™ The gamma globin genes (HBG1MDM4 encodes a nuclear protein that contains a p53 binding domain at the N terminus and a RING finger domain at the C terminus, and shows structural similarity to p53 binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain.