JIP4 Polyclonal Antibody, 50ul Hepatocytes The genes encoding the type

The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13

Mutations in this gene have been associated with medulloblastomas| secretory breast carcinomas and other cancers

and may be involved in UV-induced signal transduction

suggesting that this gene may be involved in tumor progression

Mutations in ROR2 can cause brachydactyly type B

JIP4 Polyclonal Antibody, 50ul Hepatocytes The genes encoding the typeThis gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen activated protein kinases and mediates c Jun terminal kinase signaling. This protein also binds to kinesin 1 and may be involved in microtubule based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants.