ATR Polyclonal Antibody, 50ul Centrifuges Several alternatively spliced transcripts have

Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins

Catalytic activity:Release of a C-terminal amino acid with broad specificity

The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2

It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting

Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity

ATR Polyclonal Antibody, 50ul Centrifuges Several alternatively spliced transcripts haveThe protein encoded by ATR (ATR serine threonine kinase) belongs the PI3 PI4 kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1,