Shc(Phospho Tyr349) Polyclonal Antibody, 50ul Sealing Film Alternative splicing of this gene

Alternative splicing of this gene results in several transcript variants which encode different isoforms

nucleolus site being often related to storage

The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains

Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction

|PTM:Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity

Shc(Phospho Tyr349) Polyclonal Antibody, 50ul Sealing Film Alternative splicing of this geneThis gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2 SOS complex. p66Shc is not involved in Ras activation.