Fer(Phospho Tyr402) Polyclonal Antibody, 50ul Cellular Function Assays ITCH (itchy E3 ubiquitin protein

ITCH (itchy E3 ubiquitin protein ligase) encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases

and that loss of this protection results in cell death and sensorineural hearing loss

and repression of IgE receptor expression

This gene encodes a class III member of the beta tubulin protein family

The first mRNA transcript isolated for GCFC2 (GC-rich sequence DNA-binding factor 2) was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204)

Fer(Phospho Tyr402) Polyclonal Antibody, 50ul Cellular Function Assays ITCH (itchy E3 ubiquitin proteinThe protein encoded by this gene is a member of the FPS FES family of non transmembrane receptor tyrosine kinases. It regulates cell cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X.