Human Interleukin-1 Receptor-associated Kinase 1, IRAK1 ELISA Kit, 96T Molecular Weight Markers C-terminal

C-terminal

The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells

which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity)

suggesting an involvement in the regulation of processes such as cell survival

while the carboxy-terminal region is protease sensitive

Human Interleukin-1 Receptor-associated Kinase 1, IRAK1 ELISA Kit, 96T Molecular Weight Markers C-terminalSerine threonine protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll like receptor (TLR) and IL 1R signaling pathways. Is rapidly recruited by MYD88 to the receptor signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins