FILA2 Rabbit Polyclonal Antibody, 100ul Molecular Sciences Quality control in the endoplasmic

Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins

Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases

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Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and PDZ domain binding

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FILA2 Rabbit Polyclonal Antibody, 100ul Molecular Sciences Quality control in the endoplasmicThe filaggrin like protein encoded by this gene is upregulated by calcium proteolyzed by calpain 1 and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact in addition to providing a physical barrier C terminal fragments of this protein display antimicrobial activity