PDE4B Rabbit Polyclonal Antibody, 20ul ROS/Nitric Oxide Detection Histamine regulates several physiologic processes

Histamine regulates several physiologic processes

Mutations in this gene have been associated with autosomal recessive mental retardation

and has been found in complexes with these proteins as well as the hematopoietic transcription factor GATA-1

Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism

tissue specificity:Expressed in lung

PDE4B Rabbit Polyclonal Antibody, 20ul ROS/Nitric Oxide Detection Histamine regulates several physiologic processesThis gene is a member of the type IV cyclic AMP (cAMP) specific cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding