MDM2 Polyclonal Antibody, 100ul[BT-AP05303] DNA/RNA Isolation & Purification COPS2 is an essential component

COPS2 is an essential component of the COP9 signalosome complex (CSN)

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An important paralog of this gene is ITGB4

This gene encodes one of the major intermediate filament proteins of mature astrocytes

Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses

MDM2 Polyclonal Antibody, 100ul[BT-AP05303] DNA/RNA Isolation & Purification COPS2 is an essential componentMDM2 encodes a nuclear localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many