Nibrin Polyclonal Antibody, 100ul[BT-AP06022] Syringe Filter The upstream stimulatory factor 2

The upstream stimulatory factor 2 can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes

PIK3R1 encodes the 85 kD regulatory subunit

This gene forms the basis for the Kidd blood group system

and may constitute a subfamily of the DOK genes

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen

Nibrin Polyclonal Antibody, 100ul[BT-AP06022] Syringe Filter The upstream stimulatory factor 2Mutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.