p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets The WW domains are essential

The WW domains are essential for localization to nuclear speckles

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis

Polymorphisms in the gene encoding this protein are associated with impaired transporter function

Following binding of gonadotropin-releasing hormone

Pseudogenes of this gene are present on chromosomes 1| 3| 9| 12 and 20| and on the X chromosome

p57(Phospho Thr310) Polyclonal Antibody, 100ul Aspirating Pipets The WW domains are essentialThis gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight binding, strong inhibitor of several G1 cyclin Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.