ErbB-3 Polyclonal Antibody, 100ul[BT-AP03042] Primary Antibodies 1998 [PubMed: 9616133])

1998 [PubMed: 9616133])

is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore

During mitosis it is associated with chromosomes

Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation

Mutations in BTK cause X-linked agammaglobulinemia type 1

ErbB-3 Polyclonal Antibody, 100ul[BT-AP03042] Primary Antibodies 1998 [PubMed: 9616133])ERBB3 encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation