Human Dickkopf-related Protein 4, DKK4 ELISA Kit, 96T Recombinant Ab Production This gene encodes a ubiquitin

This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex

and modulating their activity

PubMed: 17635946

Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18

The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)

Human Dickkopf-related Protein 4, DKK4 ELISA Kit, 96T Recombinant Ab Production This gene encodes a ubiquitinAntagonizes canonical Wnt signaling by inhibiting LRP5 6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5 6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone